Ingredient Encyclopedia

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Ingredient Encyclopedia

Gluconolactone (PHA) – Benefits, Side Effects & Uses

by ThankMeNow Editors on Sep 10, 2025
Gluconolactone ($C_{6}H_{10}O_{6}$) is a naturally occurring Polyhydroxy Acid (PHA) produced through the oxidation of glucose. It is structurally unique among exfoliants because of its high density of hydroxyl groups, which confer exceptional humectant properties similar to Glycerin. With a molecular weight of approximately 178 g/mol, it is significantly larger than Glycolic Acid (76 g/mol), resulting in a "controlled entry" into the stratum corneum that minimizes sensory irritation (stinging). Beyond exfoliation, Gluconolactone acts as a chelating agent, trapping heavy metals that can catalyze oxidative damage, and it has been shown in clinical studies to provide a 50% increase in protection against UV radiation-induced redness when compared to traditional AHAs.