Ingredient Encyclopedia

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Discover what’s inside your skincare — from retinol to aloe vera — with clear guides on benefits, uses, and safety.

Ingredient Encyclopedia

Dipotassium Glycyrrhizate – Benefits, Side Effects & Uses

by ThankMeNow Editors on Sep 10, 2025
The clinical efficacy of Dipotassium Glycyrrhizate in 2026 is centered on its ability to regulate the NF-κB signaling pathway—the body's internal "alarm system" for inflammation. Unlike surface-level cooling agents, this licorice-derived salt penetrates the upper layers of the epidermis to inhibit the enzymes responsible for redness and swelling (specifically hyaluronidase). While it is often discussed alongside its cousin, Glycyrrhetinic Acid, the Dipotassium salt is preferred in modern formulations for its superior water solubility and stability. In professional post-care, it is utilized as a "Biological Buffer," reducing the incidence of Post-Inflammatory Hyperpigmentation (PIH) by ensuring that the skin remains "quiet" during the critical 48-hour recovery window following microneedling or high-strength chemical peels.